Article

Defining Cardiac Recovery at Single Cell Resolution

2022-09-13

Abstract excerpt

Recovery of cardiac function is the ultimate goal of heart failure therapy. Unfortunately, cardiac recovery remains a rare and poorly understood phemomenon. Herein, we performed single nucleus RNA-sequencing (snRNA-seq) from non-diseased donors and heart failure patients. By comparing patients who recovered LV systolic function following LV assist device implantation to those who did not recover and donors, we def...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2dd26829-f95a-594f-b6dd-810758a7c602
DOI: 10.1101/2022.09.11.507463

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Defining Cardiac Recovery at Single Cell ResolutionDOI 10.1101/2022.09.11.507463Read

Targeting RUNX1 in Macrophages Facilitates Cardiac RecoverySemantic proximity Read

Single-cell transcriptomics reveals cell-type-specific diversification in human heart failureSemantic proximity Read

Deciphering human heart failure with preserved ejection fraction (HFpEF) at single cell resolutionSemantic proximity Read

Single Cell Transcriptomics Reveals Cell Type Specific Diversification in Human Heart FailureSemantic proximity Read

Integrated single-cell and spatial multiomic analysis reveals widespread reactivation of developmental programs in diseased human heartsSemantic proximity Read

Comprehensive Integration of Single-Cell Transcriptional Profiling Reveals the Heterogeneities of Non-cardiomyocytes in Healthy and Ischemic HeartsSemantic proximity Read

Single cell transcriptomic analyses of human heart failure with preserved ejection fractionSemantic proximity Read

Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac functionSemantic proximity Read

Beyond cardiomyocytes: Cellular diversity in the heart's response to exerciseSemantic proximity Read

Cells and gene expression programs in the adult human heartSemantic proximity Read

Transcriptional and Cellular Diversity of the Human HeartSemantic proximity Read

Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injurySemantic proximity Read