Integrated single-cell and spatial multiomic analysis reveals widespread reactivation of developmental programs in diseased human hearts

Abstract excerpt

<h4>ABSTRACT</h4> The first organ to develop in utero, the human heart undergoes significant changes during development and must sustain its function over a lifetime. To better characterize molecular changes in human cardiac cell-types across sex, aging, developmental and disease, we analyzed single nucleus RNA sequencing (snRNA-seq) datasets from 299 donors, identifying many more differentially expressed genes (...

Topics

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• Atherosclerosis and Cardiovascular Diseases
• Cardiac Fibrosis and Remodeling
• Cardiomyopathy and Myosin Studies
• Congenital heart defects research
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

63e8f4a3-0512-5199-a9a7-4579501932e8

DOI

10.1101/2025.04.01.646460