Article
Validation and Development of an Escherichia coli Riboflavin Pathway Phenotypic Screen Hit as a Small-Molecule Ligand of the Flavin Mononucleotide Riboswitch.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018
Balibar Carl J, Villafania Artjohn, Barbieri Christopher M, Murgolo Nick, Roemer Terry, Wang Hao, Howe John A
Abstract excerpt
A riboflavin biosynthesis pathway-specific phenotypic screen using a library of compounds, all with unspecified antibiotic activity, identified one small molecule later named ribocil, for which intrinsic antibacterial activity against Escherichia coli was completely suppressed by addition of exogenous riboflavin to the bacterial growth medium. The ability of riboflavin to suppress the activity of ribocil, and...
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