Article

Gene expression-based identification of antigen-responsive CD8 <sup>+</sup> T cells on a single-cell level

2019-06-19

Abstract excerpt

CD8 + T cells are important effectors of adaptive immunity against pathogens, tumors and self antigens. Here, we asked how human cognate antigen-responsive CD8 + T cells and their receptors could be identified in unselected single-cell gene expression data. Single-cell RNA sequencing and qPCR of dye-labelled antigen-specific cells identified large gene sets that were congruently up- or downregulated in virus-res...

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Literature Corpus work: 0281bae8-3b75-5af5-ad28-87df254f7f98
DOI: 10.1101/673707

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