Article

CHANGE-seq-BE enables simultaneously sensitive and unbiased <i>in vitro</i> profiling of base editor genome-wide activity

2024-03-30

Abstract excerpt

Base editors ( BE ) enable programmable conversion of nucleotides in genomic DNA without double-stranded breaks and have substantial promise to become new transformative genome editing medicines. Sensitive and unbiased detection of base editor off-target effects is important for identifying safety risks unique to base editors and translation to human therapeutics, as well as accurate use in life sciences research...

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Literature Corpus work: 2333ec97-d7c7-560c-a584-0adbc95f0337
DOI: 10.1101/2024.03.28.586621

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