Article
Mutational landscape and significance across 12 major cancer types.
Nature - 17 Oct 2013
Kandoth Cyriac, McLellan Michael D, Vandin Fabio, Ye Kai, Niu Beifang, Lu Charles, Xie Mingchao, Zhang Qunyuan, McMichael Joshua F, Wyczalkowski Matthew A, Leiserson Mark D M, Miller Christopher A, Welch John S, Walter Matthew J, Wendl Michael C, Ley Timothy J, Wilson Richard K, Raphael Benjamin J, Ding Li
Abstract excerpt
The Cancer Genome Atlas (TCGA) has used the latest sequencing and analysis methods to identify somatic variants across thousands of tumours. Here we present data and analytical results for point mutations and small insertions/deletions from 3,281 tumours across 12 tumour types as part of the TCGA Pan-Cancer effort. We illustrate the distributions of mutation frequencies, types and contexts across tumour types,...
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