Article

Aberrant expression of histone H2B variants reshape chromatin and alter oncogenic gene expression programs

2024-11-21

Abstract excerpt

<h4>ABSTRACT</h4> Chromatin architecture governs DNA accessibility and gene expression. Thus, any perturbations to chromatin can significantly alter gene expression programs and promote disease. Prior studies demonstrate that every amino acid in a histone is functionally significant, and that even a single amino acid substitution can drive specific cancers. We previously observed that naturally occurring H2B vari...

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Literature Corpus work: 71f9ff57-c005-568f-99a5-a3f6876c0b34
DOI: 10.1101/2024.11.18.624207

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