Article

Proteomic characterization of GSK3β knockout shows altered cell adhesion and metabolic pathway utilisation in colorectal cancer cells.

2021-01-26

Abstract excerpt

<h4>ABSTRACT</h4> Glycogen-specific kinase (GSK3β) is an integral regulator of the Wnt signalling pathway as well as many other diverse signalling pathways and processes. Dys-regulation of GSK3β is implicated in many different pathologies, including neurodegenerative disorders as well as many different tumour types. In the context of tumour development, GSK3β has been shown to play both oncogenic and tumour suppr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9323e7cf-91d1-5d5a-8d03-0d5d943e5e3d
DOI: 10.1101/2021.01.26.428222

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Proteomic characterization of GSK3β knockout shows altered cell adhesion and metabolic pathway utilisation in colorectal cancer cells.DOI 10.1101/2021.01.26.428222Read

Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?Semantic proximity Read

The enzyme glycogen synthase kinase-3 is associated with specific forms of oncogenesis; what more do we need to know to achieve clinical benefit?Semantic proximity Read

Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity-Diverse effects on cell growth, metabolism and cancer.Semantic proximity Read

GSK3beta: role in therapeutic landscape and development of modulators.Semantic proximity Read

The Landscape of Glycogen Synthase Kinase-3 Beta Genomic Alterations in Cancer.Semantic proximity Read

Kinase-Inactive Glycogen Synthase Kinase 3β Promotes Wnt Signaling and Mammary TumorigenesisSemantic proximity Read

Kinase GSK3β functions as a suppressor in colorectal carcinoma through the FTO‐mediated MZF1/c‐Myc axisSemantic proximity Read

Deregulated GSK3 Sustains Gastrointestinal Cancer Cells Survival by Modulating Human Telomerase Reverse Transcriptase and TelomeraseSemantic proximity Read

Complex formation and reciprocal regulation between GSK3β and C3G.Semantic proximity Read

Binding of GSK3beta to the APC-beta-catenin complex and regulation of complex assembly.Semantic proximity Read

Activation of p53-dependent apoptosis by acute ablation of glycogen synthase kinase-3beta in colorectal cancer cells.Semantic proximity Read

Expression and characterization of GSK-3 mutants and their effect on beta-catenin phosphorylation in intact cells.Semantic proximity Read