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Article

Activation of p53-dependent apoptosis by acute ablation of glycogen synthase kinase-3beta in colorectal cancer cells.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2005

Ghosh Jagadish C, Altieri Dario C

Abstract excerpt

PURPOSE: The restoration of checkpoint mechanisms may provide a rational anticancer approach, but the molecular circuitries of how this can be achieved therapeutically are poorly understood. A pivotal signaling network in colorectal cancer cells involves glycogen synthase kinase-3beta (GSK3beta),...

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Identifiers

PMID: 15958644
DOI: 10.1158/1078-0432.CCR-04-2624

Genes

MDM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15958644-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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