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Article

Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?

Biochemical Society transactions - 1 Nov 2004

Patel S, Doble B, Woodgett J R

Abstract excerpt

Glycogen synthase kinase-3 is an unusual protein serine/threonine kinase that, unlike most of its 500-odd relatives in the genome, is active under resting conditions and is inactivated upon cell stimulation. The two mammalian isoforms, GSK-3alpha and beta, play largely overlapping roles and have been implicated in a variety of human pathologies, including Type II diabetes, Alzheimer's disease, bipolar disorder...

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Identifiers

PMID: 15494020
DOI: 10.1042/BST0320803
PMCID: PMC4485494

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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