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Deregulated GSK3 Sustains Gastrointestinal Cancer Cells Survival by Modulating Human Telomerase Reverse Transcriptase and Telomerase

10 Nov 2009

Abstract excerpt

PURPOSE: Glycogen synthase kinase-3beta (GSK3beta) regulates multiple cell signaling pathways and has been implicated in glucose intolerance, neurodegenerative disorders, and inflammation. We investigated the expression, activity, and putative pathologic role of GSK3beta in gastrointestinal, pancreatic, and liver cancers. EXPERIMENTAL DESIGN: Colon, stomach, pancreatic, and liver cancer cell lines; nonneoplastic...

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PMID: 19903789
DOI: 10.1158/1078-0432.ccr-09-0973

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