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The Landscape of Glycogen Synthase Kinase-3 Beta Genomic Alterations in Cancer.

Molecular cancer therapeutics - 1 Jan 2021

Borden Brittany A, Baca Yasmine, Xiu Joanne, Tavora Fabio, Winer Ira, Weinberg Benjamin A, Vanderwalde Ari M, Darabi Sourat, Korn W Michael, Mazar Andrew P, Giles Francis J, Crawford Lorin, Safran Howard, El-Deiry Wafik S, Carneiro Benedito A

Abstract excerpt

Glycogen synthase kinase-3β (GSK-3β), a serine/threonine kinase, has been implicated in the pathogenesis of many cancers, with involvement in cell-cycle regulation, apoptosis, and immune response. Small-molecule GSK-3β inhibitors are currently undergoing clinical investigation. Tumor sequencing has revealed genomic alterations in GSK-3β, yet an assessment of the genomic landscape in malignancies is lacking. This...

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PMID: 33087512
DOI: 10.1158/1535-7163.MCT-20-0497

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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