The enzyme glycogen synthase kinase-3 is associated with specific forms of oncogenesis; what more do we need to know to achieve clinical benefit?

Abstract excerpt

Mutations in glycogen synthase kinase-3 (GSK3) are associated with oncogenesis, but the opposing roles of GSK3 in tumour suppression and promotion, inadequate methods for assessing GSK3 activity and off-target effects of commonly used inhibitors on cell proliferation have stalled progress to clinical benefit. This review evaluates evidence linking GSK3 dysfunction to specific cancer types and explores how this...

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