Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity-Diverse effects on cell growth, metabolism and cancer.

doi:10.1016/j.bbamcr.2016.09.004

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Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity-Diverse effects on cell growth, metabolism and cancer.

Biochimica et biophysica acta - 1 Dec 2016

McCubrey James A, Rakus Dariusz, Gizak Agnieszka, Steelman Linda S, Abrams Steve L, Lertpiriyapong Kvin, Fitzgerald Timothy L, Yang Li V, Montalto Giuseppe, Cervello Melchiorre, Libra Massimo, Nicoletti Ferdinando, Scalisi Aurora, Torino Francesco, Fenga Concettina, Neri Luca M, Marmiroli Sandra, Cocco Lucio, Martelli Alberto M

Abstract excerpt

Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that participates in an array of critical cellular processes. GSK-3 was first characterized as an enzyme that phosphorylated and inactivated glycogen synthase. However, subsequent studies have revealed that this moon-lighting protein is involved in numerous signaling pathways that regulate not only metabolism but also have roles in: apoptosis, cell...

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PMID: 27612668
DOI: 10.1016/j.bbamcr.2016.09.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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