Article

Redox signaling regulates breast cancer metastasis via HIF1α-stimulated EMT dynamics and metabolic reprogramming

2022-08-30

Abstract excerpt

Metastasis is orchestrated by phenotypic and metabolic reprogramming underlying tumor aggressiveness. Redox signaling by mammary tumor knockdown (KD) of the antioxidant glutathione peroxidase 2 (GPx2) enhanced metastasis via dynamic changes in epithelial-to-mesenchymal transition. Single cell RNA sequencing (scRNA-seq) of the control and PyMT/GPx2 KD mammary tumor revealed six luminal and one basal/mesenchymal lik...

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Literature Corpus work: 931ecb8e-0f75-5e80-9772-c5bc22ff2e6f
DOI: 10.1101/2022.08.29.503508

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