Article

Glutathione Peroxidase 8 (GPX8)-IL6 axis is essential in maintaining breast cancer mesenchymal stem-like state and aggressive phenotype

2019-10-25

Abstract excerpt

Metabolic reprogramming as a downstream result of oncogenic signaling pathways has been described as a hallmark of cancer. Here, we describe a reverse scenario in which a metabolic enzyme regulates cancer cell behavior by triggering a signaling pathway. We find that glutathione peroxidase 8 (GPX8), a poorly characterized redox enzyme that resides in the endoplasmic reticulum, is upregulated during the epithelial-t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: dbca94f3-c58a-56d5-bc6a-2e1bab9f5467
DOI: 10.1101/818245

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Glutathione Peroxidase 8 (GPX8)-IL6 axis is essential in maintaining breast cancer mesenchymal stem-like state and aggressive phenotypeDOI 10.1101/818245Read

The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype.Semantic proximity Read

Redox signaling regulates breast cancer metastasis via HIF1α-stimulated EMT dynamics and metabolic reprogrammingSemantic proximity Read

Redoxhigh phenotype mediated by KEAP1/STK11/SMARCA4/NRF2 mutations diminishes tissue-resident memory CD8+ T cells and attenuates the efficacy of immunotherapy in lung adenocarcinoma.Semantic proximity Read

p66ShcA promotes malignant breast cancer phenotypes by alleviating energetic and oxidative stress.Semantic proximity Read

ALDHHigh Breast Cancer Stem Cells Exhibit a Mesenchymal-Senescent Hybrid Phenotype, with Elevated Metabolic and Migratory Activities.Semantic proximity Read

A Comprehensive Analysis of the Glutathione Peroxidase 8 (GPX8) in Human CancerSemantic proximity Read

Glyoxalase 1 gene is highly expressed in basal-like human breast cancers and contributes to survival of ALDH1-positive breast cancer stem cellsSemantic proximity Read

The Epithelial to Mesenchymal Transition Promotes Glutamine Independence by Suppressing GLS2 ExpressionSemantic proximity Read

Glutathione dynamics is a potential predictive and therapeutic trait for neoadjuvant chemotherapy response in bladder cancer.Semantic proximity Read

Cancer Metabostemness and Metabolic Reprogramming via P2X7 ReceptorSemantic proximity Read

GPX4 Defines an Immune-Cold Phenotype and Poor Prognosis in Resected Lung Adenocarcinoma.Semantic proximity Read

Glutaredoxin‐1 promotes lymphangioleiomyomatosis progression through inhibiting Bim‐mediated apoptosis via COX2/PGE2/ERK pathwaySemantic proximity Read