Article
The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 2020
Khatib Anees, Solaimuthu Balakrishnan, Ben Yosef Michal, Abu Rmaileh Areej, Tanna Mayur, Oren Gidi, Schlesinger Frisch Michal, Axelrod Jonathan H, Lichtenstein Michal, Shaul Yoav D
Abstract excerpt
One of the emerging hallmarks of cancer illustrates the importance of metabolic reprogramming, necessary to synthesize the building blocks required to fulfill the high demands of rapidly proliferating cells. However, the proliferation-independent instructive role of metabolic enzymes in tumor plasticity is still unclear. Here, we provide evidence that glutathione peroxidase 8 (GPX8), a poorly characterized enzyme...
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