Article
p66ShcA promotes malignant breast cancer phenotypes by alleviating energetic and oxidative stress.
Redox biology - 1 Apr 2024
Lewis Kyle, La Selva Rachel, Maldonado Elias, Annis Matthew G, Najyb Ouafa, Cepeda Cañedo Eduardo, Totten Stephanie, Hébert Steven, Sabourin Valérie, Mirabelli Caitlynn, Ciccolini Emma, Lehuédé Camille, Choinière Luc, Russo Mariana, Avizonis Daina, Park Morag, St-Pierre Julie, Kleinman Claudia L, Siegel Peter M, Ursini-Siegel Josie
Abstract excerpt
Significant efforts have focused on identifying targetable genetic drivers that support the growth of solid tumors and/or increase metastatic ability. During tumor development and progression to metastatic disease, physiological and pharmacological selective pressures influence parallel adaptive strategies within cancer cell sub-populations. Such adaptations allow cancer cells to withstand these stressful...
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