Back to search

Article

Interconnected axes of phenotypic plasticity drive coordinated cellular behaviour and worse clinical outcomes in breast cancer

2025-11-26

Abstract excerpt

Phenotypic plasticity plays a key role in cancer progression and metastasis, enabling cancer cells to adapt and evolve, but precisely how distinct axes governing phenotypic plasticity interact to shape tumour progression and patient outcomes remains unclear. We investigated five major interconnected axes of plasticity in ER-positive (ER+) breast cancer: Metabolic Reprogramming, Epithelial-to-Mesenchymal Plasticity...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6225aed0-cdaa-51f3-b90c-aaa6c5e65964
DOI
10.1101/2025.11.23.688595
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Interconnected axes of phenotypic plasticity drive coordinated cellular behaviour and worse clinical outcomes in breast cancerDOI 10.1101/2025.11.23.688595
Increased prevalence of hybrid epithelial/mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancerSemantic proximity
Multi-modal transcriptomic analysis unravels enrichment of hybrid epithelial/mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancerSemantic proximity
The Flick of a Switch: Conferring Survival Advantage to Breast Cancer Stem Cells Through Metabolic PlasticitySemantic proximity
A systems-level analysis of the mutually antagonistic roles of RKIP and BACH1 in dynamics of cancer cell plasticitySemantic proximity
Combined Single‐Cell and Spatial Transcriptomics Reveal the Metabolic Evolvement of Breast Cancer during Early DisseminationSemantic proximity
Identifying inhibitors of epithelial-mesenchymal plasticity using a network topology-based approach.Semantic proximity
Cellular and molecular mechanisms of plasticity in cancer.Semantic proximity
Breast cancer as an example of tumour heterogeneity and tumour cell plasticity during malignant progressionSemantic proximity
Perturbation-guided mapping of colorectal cancer cell states to causal mechanismsSemantic proximity
EMT-driven plasticity prospectively increases cell–cell variability to promote therapeutic adaptation in breast cancerSemantic proximity
Discovery of multi-state gene cluster switches determining the adaptive mitochondrial and metabolic landscape of breast cancerSemantic proximity
Epithelial/mesenchymal plasticity: how have quantitative mathematical models helped improve our understanding?Semantic proximity
Select a neighboring publication to make it the new centre.