Article

Multi-modal transcriptomic analysis unravels enrichment of hybrid epithelial/mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancer

2023-10-02

Abstract excerpt

Intra-tumoral phenotypic heterogeneity promotes tumor relapse and therapeutic resistance and remains an unsolved clinical challenge. It manifests along multiple phenotypic axes and decoding the interconnections among these different axes is crucial to understand its molecular origins and to develop novel therapeutic strategies to control it. Here, we use multi-modal transcriptomic data analysis – bulk, single-cell...

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Literature Corpus work: 32368ab1-9b8a-5658-bc08-5cf93b2027d0
DOI: 10.1101/2023.09.30.558960

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