Article

A Humanized IFN-γ Mouse Model Reveals Skin Eschar Formation, Enhanced Susceptibility and Scrub Typhus Pathogenesis

2025-08-02

Abstract excerpt

Scrub typhus, caused by Orientia tsutsugamushi ( Ot ) bacteria, is a serious acute febrile illness associated with significant mortality. An estimated one million cases occur annually, with more than one billion people at risk. No effective vaccine is currently available, largely due to the complex Ot strain diversity and an incomplete understanding of protective immune mechanisms. To overcome these challenges,...

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Literature Corpus work: 9313ac61-5b63-57db-8ba0-64975213debc
DOI: 10.1101/2025.08.01.668084

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