Comparative virulence analysis of seven diverse strains of Orientia tsutsugamushi reveals a multifaceted and complex interplay of virulence factors responsible for disease

Abstract excerpt

Orientia tsutsugamushi is an obligate intracellular bacterium found in Leptotrombidium mites that causes the human disease scrub typhus. A distinguishing feature of O. tsutsugamushi is its extensive strain diversity, yet differences in virulence between strains are not well defined nor well understood. We sought to determine the bacterial drivers of pathogenicity by comparing seven strains using murine infections...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Insect symbiosis and bacterial influences
• Share to Mosquito-borne diseases and control
• Share to Vector-borne infectious diseases