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Article

Toll-Like Receptor 2 Recognizes Orientia tsutsugamushi and Increases Susceptibility to Murine Experimental Scrub Typhus.

Infection and immunity - 1 Dec 2016

Gharaibeh Mohammad, Hagedorn Monica, Lilla Stefanie, Hauptmann Matthias, Heine Holger, Fleischer Bernhard, Keller Christian

Abstract excerpt

Scrub typhus is a potentially lethal infection that is caused by the obligate intracellular bacterium Orientia tsutsugamushi The roles of Toll-like receptor 2 (TLR2) and TLR4 in innate recognition of O. tsutsugamushi have not been elucidated. By overexpression of TLR2 or TLR4 in HEK293 cells, we demonstrated that TLR2, but not TLR4, recognizes heat-stable compounds of O. tsutsugamushi that were sensitive to...

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Identifiers

PMID: 27620720
DOI: 10.1128/IAI.00185-16
PMCID: PMC5116716

Genes

TLR2
TLR4
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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