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Selective Activation of Macrophage Innate Signaling Pathways and Inflammatory Responses to <i>Orientia tsutsugamushi</i> Karp and Gilliam Strains

2026-04-26

Abstract excerpt

Orientia tsutsugamushi ( Ot ) is an obligatory intracellular bacterium that can cause scrub typhus, an emerging but severely neglected disease with high mortality rates. Ot Karp and Gilliam strains account for most reported cases in Southeast Asia. Our group has reported that Karp-infected outbred and inbred mice exhibit more severe disease outcomes than their Gilliam-infected counterparts, likely due to their e...

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Literature Corpus work
0d9873cb-dd8e-5eca-be7f-0735d910a194
DOI
10.64898/2026.04.24.720537
Open publication

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