Article

Superantigens promote <i>Staphylococcus aureus</i> bloodstream infection by eliciting pathogenic interferon-gamma (IFNγ) production that subverts macrophage function

2021-08-17

Abstract excerpt

<h4>ABSTRACT</h4> Staphylococcus aureus is a foremost bacterial pathogen responsible for a vast array of human diseases. Staphylococcal superantigens (SAgs) constitute a family of potent exotoxins secreted by S. aureus , and SAg genes are found ubiquitously in human isolates. SAgs bind directly to MHC class II molecules and T cell receptors, driving extensive T cell activation and cytokine release. Although thes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 289f3742-460c-5cc6-bd23-8aa8e377c473
DOI: 10.1101/2021.08.17.456537

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Superantigens promote <i>Staphylococcus aureus</i> bloodstream infection by eliciting pathogenic interferon-gamma (IFNγ) production that subverts macrophage functionDOI 10.1101/2021.08.17.456537Read

Superantigens promote <i>Staphylococcus aureus</i> bloodstream infection by eliciting pathogenic interferon-gamma productionSemantic proximity Read

Manipulation of Innate and Adaptive Immunity by Staphylococcal SuperantigensSemantic proximity Read

Toxic Shock Syndrome and Bacterial Superantigens: An UpdateSemantic proximity Read

Staphylococcal superantigens in colonization and diseaseSemantic proximity Read

Staphylococcal Superantigen Super-Domains in Immune EvasionSemantic proximity Read

Prevalence, Production and the Role of <i>Staphylococcus aureus</i> Superantigens in Cystic Fibrosis Lung DiseaseSemantic proximity Read

Staphylococcal Superantigens: Pyrogenic Toxins Induce Toxic ShockSemantic proximity Read

Population Analysis of Staphylococcus aureus Reveals a Cryptic, Highly Prevalent Superantigen SElW That Contributes to the Pathogenesis of BacteremiaSemantic proximity Read

Superantigens, a Paradox of the Immune ResponseSemantic proximity Read

Update on molecular diversity and multipathogenicity of staphylococcal superantigen toxinsSemantic proximity Read

The bacterial superantigen and superantigen‐like proteinsSemantic proximity Read

Bacterial Superantigens Promote Acute Nasopharyngeal Infection by Streptococcus pyogenes in a Human MHC Class II-Dependent MannerSemantic proximity Read