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Unique B Cell and Germinal Center Responses in Mice with Severe versus Mild <i>Orientia tsutsugamushi</i> Infection

2025-04-01

Abstract excerpt

The intracellular bacterium Orientia tsutsugamushi ( Ot ) is the causative agent of scrub typhus, an emerging and neglected tropical disease. Immunity against Ot infection in patients is known to be short-lived, as circulating antibodies can wane around one-year post-infection. However, its underlying mechanisms remain unclear; host immune signatures to clinically prevalent Ot strains are also undefined. In th...

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Literature Corpus work
bd3c3b4e-7ab1-5fe5-b178-867877a3c371
DOI
10.1101/2025.03.27.645674
Open publication

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