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Article

A mouse model for the human pathogen Salmonella typhi.

Cell host & microbe - 21 Oct 2010

Song Jeongmin, Willinger Tim, Rongvaux Anthony, Eynon Elizabeth E, Stevens Sean, Manz Markus G, Flavell Richard A, Galán Jorge E

Abstract excerpt

Salmonella enterica serovar Typhi (S. Typhi) causes typhoid fever, a life-threatening human disease. The lack of animal models due to S. Typhi's strict human host specificity has hindered its study and vaccine development. We find that immunodeficient Rag2(-/-) γc(-/-) mice engrafted with human fetal liver hematopoietic stem and progenitor cells are able to support S. Typhi replication and persistent infection....

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Identifiers

PMID: 20951970
DOI: 10.1016/j.chom.2010.09.003
PMCID: PMC2972545

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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