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Comparative virulence analysis of seven diverse strains of <i>Orientia tsutsugamushi</i> reveals a multifaceted and complex interplay of virulence factors responsible for disease

2025-01-04

Abstract excerpt

Orientia tsutsugamushi is an obligate intracellular bacterium found in Leptotrombidium mites that causes the human disease scrub typhus. A distinguishing feature of O. tsutsugamushi is its extensive strain diversity, yet differences in virulence between strains are not well defined nor well understood. We sought to determine the bacterial drivers of pathogenicity by comparing murine infections using seven strain...

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Literature Corpus work
673241d3-769b-5d76-8e92-b1cf9371ddff
DOI
10.1101/2024.12.18.629091
Open publication

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Comparative virulence analysis of seven diverse strains of <i>Orientia tsutsugamushi</i> reveals a multifaceted and complex interplay of virulence factors responsible for diseaseDOI 10.1101/2024.12.18.629091
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