Article
ATHLATES: accurate typing of human leukocyte antigen through exome sequencing.
Nucleic acids research - 1 Aug 2013
Liu Chang, Yang Xiao, Duffy Brian, Mohanakumar Thalachallour, Mitra Robi D, Zody Michael C, Pfeifer John D
Abstract excerpt
Human leukocyte antigen (HLA) typing at the allelic level can in theory be achieved using whole exome sequencing (exome-seq) data with no added cost but has been hindered by its computational challenge. We developed ATHLATES, a program that applies assembly, allele identification and allelic pair inference to short read sequences, and applied it to data from Illumina platforms. In 15 data sets with adequate...
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