Article
HLAscan: genotyping of the HLA region using next-generation sequencing data.
BMC bioinformatics - 12 May 2017
Ka Sojeong, Lee Sunho, Hong Jonghee, Cho Yangrae, Sung Joohon, Kim Han-Na, Kim Hyung-Lae, Jung Jongsun
Abstract excerpt
BACKGROUND: Several recent studies showed that next-generation sequencing (NGS)-based human leukocyte antigen (HLA) typing is a feasible and promising technique for variant calling of highly polymorphic regions. To date, however, no method with sufficient read depth has completely solved the alle...
Topics
- Alleles
- Area Under Curve
- Exons
- Genotype
- HLA Antigens
- HLA-A Antigens
- HLA-B Antigens
- HLA-DRB1 Chains
- HapMap Project
- High-Throughput Nucleotide Sequencing
- Histocompatibility Testing
- Humans
- ROC Curve
- Sequence Analysis, DNA