Article

IF1 restrains excessive elevation of the mitochondrial membrane potential and safeguards the epithelial state of human induced pluripotent stem cells

2026-06-17

Abstract excerpt

Human pluripotent stem cells (hPSCs) rely predominantly on glycolysis and exhibit relatively low mitochondrial respiration. Under these conditions, the mitochondrial F1Fo ATP synthase tends to operate in reverse mode, hydrolyzing ATP. ATP synthase inhibitory factor subunit 1 (IF1) inhibits this F1Fo ATP hydrolysis, but its role in hPSCs remains unclear. Here, we generated human induced pluripotent stem cells (hiPS...

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Literature Corpus work: 930224f3-3089-5183-b825-01e6794e3f83
DOI: 10.64898/2026.06.16.732339

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