Article

PDK1-dependent metabolic reprogramming regulates stemness and tumorigenicity of osteosarcoma stem cells through ATF3

2024-12-18

Abstract excerpt

<title>Abstract</title> <p>Osteosarcoma stem cells (OSCs) are characterized by their self-renewal and multilineage differentiation abilities, contributing to osteosarcoma (OS) malignancy. The Warburg effect describes cancer cells’ preference for glycolysis over mitochondrial oxidative phosphorylation (OXPHOS) for energy production. Unlike differentiated cancer cells, cancer stem cells exhibit unique and diverse m...

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Literature Corpus work: 1f2c0651-8356-5761-9eca-11ae0d262e55
DOI: 10.21203/rs.3.rs-5372467/v1

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