Article
Up-regulation of the ATPase inhibitory factor 1 (IF1) of the mitochondrial H+-ATP synthase in human tumors mediates the metabolic shift of cancer cells to a Warburg phenotype.
The Journal of biological chemistry - 13 Aug 2010
Sánchez-Cenizo Laura, Formentini Laura, Aldea Marcos, Ortega Alvaro D, García-Huerta Paula, Sánchez-Aragó María, Cuezva José M
Abstract excerpt
The H(+)-ATP synthase is a reversible engine of mitochondria that synthesizes or hydrolyzes ATP upon changes in cell physiology. ATP synthase dysfunction is involved in the onset and progression of diverse human pathologies. During ischemia, the ATP hydrolytic activity of the enzyme is inhibited by the ATPase inhibitory factor 1 (IF1). The expression of IF1 in human tissues and its participation in the...
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