Article
Mitochondrial pyruvate carrier function determines cell stemness and metabolic reprogramming in cancer cells.
Oncotarget - 11 Jul 2017
Li Xiaoli, Han Gaoyang, Li Xiaoran, Kan Quancheng, Fan Zhirui, Li Yaqing, Ji Yasai, Zhao Jing, Zhang Mingzhi, Grigalavicius Mantas, Berge Viktor, Goscinski Mariusz Adam, Nesland Jahn M, Suo Zhenhe
Abstract excerpt
One of the remarkable features of cancer cells is aerobic glycolysis, a phenomenon known as the "Warburg Effect", in which cells rely preferentially on glycolysis instead of oxidative phosphorylation (OXPHOS) as the main energy source even in the presence of high oxygen tension. Cells with dysfunctional mitochondria are unable to generate sufficient ATP from mitochondrial OXPHOS, and then are forced to rely on...
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