Article

SwiftTCR: Efficient computational docking protocol of TCRpMHC-I complexes using restricted rotation matrices

2024-06-01

Abstract excerpt

The T cell’s ability to discern self and non-self depends on its T cell receptor (TCR), which recognizes peptides presented by MHC molecules. Understanding this TCR-peptide-MHC (TCRpMHC) interaction is important for cancer immunotherapy design, tissue transplantation, pathogen identification, and autoimmune disease treatments. Understanding the intricacies of TCR recognition, encapsulated in TCRpMHC structures, re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b285bfc5-cf6f-53ed-a33e-d04646025459
DOI: 10.1101/2024.05.27.596020

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SwiftTCR: Efficient computational docking protocol of TCRpMHC-I complexes using restricted rotation matricesDOI 10.1101/2024.05.27.596020Read

TCR3d: The T cell receptor structural repertoire databaseSemantic proximity Read

Computationally profiling peptide:MHC recognition by T-cell receptors and T-cell receptor-mimetic antibodiesSemantic proximity Read

Computationally profiling peptide:MHC recognition by T-cell receptors and T-cell receptor-mimetic antibodiesSemantic proximity Read

TCR-FramePose: a local-frame representation for decomposing global docking and CDR3 loop geometry in TCR-pMHC recognitionSemantic proximity Read

Conserved T cell receptor usage underpins recognition of CD1c presenting a mycobacterial lipidSemantic proximity Read

SwiftMHC: A High-Speed Attention Network for MHC-Bound Peptide Identification and 3D ModelingSemantic proximity Read

Structure modeling and specificity of peptide-MHC class I interactions using geometric deep learningSemantic proximity Read

TCR-BERT: learning the grammar of T-cell receptors for flexible antigen-xbinding analysesSemantic proximity Read

Benchmarking unsupervised methods for inferring TCR specificitySemantic proximity Read

Integrated analysis and annotation for T-cell receptor sequences using TCRosettaSemantic proximity Read

A comprehensive benchmarking for evaluating TCR embeddings in modeling TCR-epitope interactionsSemantic proximity Read

STRUMP-I: Structure-based machine learning approach to pMHC-I binding prediction using force field energy featuresSemantic proximity Read