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The human T‐cell receptor repertoire in health and disease and potential for omics integration

17 Jul 2020

Abstract excerpt

The adaptive immune system arose 600 million years ago in a cold-blooded fish. Over countless generations, our antecedents tuned the function of the T-cell receptor (TCR). The TCR system is arguably the most complex known to science. The TCR evolved hypervariability to fight the hypervariability of pathogens and cancers that look to consume our resources. This review describes the genetics and architecture of the...

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PMID: 32677130
DOI: 10.1111/imcb.12377

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