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Article

T cell receptor convergence is an indicator of antigen-specific T cell response in cancer immunotherapies

9 Nov 2022

Abstract excerpt

T cells are potent at eliminating pathogens and playing a crucial role in the adaptive immune response. T cell receptor (TCR) convergence describes T cells that share identical TCRs with the same amino acid sequences but have different DNA sequences due to codon degeneracy. We conducted a systematic investigation of TCR convergence using single-cell immune profiling and bulk TCRβ-sequence (TCR-seq) data obtained...

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PMID: 36350695
DOI: 10.7554/elife.81952

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