Article
Effects of APOE ε2 allele on basal forebrain functional connectivity in mild cognitive impairment.
CNS neuroscience & therapeutics - 1 Feb 2023
Liu Xiaocao, Zeng Qingze, Luo Xiao, Li Kaicheng, Xu Xiaopei, Hong Luwei, Li Jixuan, Guan Xiaojun, Xu Xiaojun, Huang Peiyu, Zhang Min-Ming
Abstract excerpt
BACKGROUND: Basal forebrain cholinergic system (BFCS) dysfunction is associated with cognitive decline in Alzheimer's disease (AD) and mild cognitive impairment (MCI). Apolipoprotein E (APOE) ε2 is a protective genetic factor in AD and MCI, and cholinergic sprouting depends on APOE. OBJECTIVE: We...
Topics
- Humans
- Apolipoprotein E2
- Alzheimer Disease
- Apolipoprotein E3
- Alleles
- Basal Forebrain
- Apolipoproteins E
- Cognitive Dysfunction
- Genotype