Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of APOE ε2 allele on basal forebrain functional connectivity in mild cognitive impairment.

CNS neuroscience & therapeutics - 1 Feb 2023

Liu Xiaocao, Zeng Qingze, Luo Xiao, Li Kaicheng, Xu Xiaopei, Hong Luwei, Li Jixuan, Guan Xiaojun, Xu Xiaojun, Huang Peiyu, Zhang Min-Ming

Abstract excerpt

BACKGROUND: Basal forebrain cholinergic system (BFCS) dysfunction is associated with cognitive decline in Alzheimer's disease (AD) and mild cognitive impairment (MCI). Apolipoprotein E (APOE) ε2 is a protective genetic factor in AD and MCI, and cholinergic sprouting depends on APOE. OBJECTIVE: We investigated the effect of the APOE ε2 allele on BFCS functional connectivity (FC) in cognitively normal (CN) subjects...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Apolipoprotein E2

Share to Apolipoprotein E3

Share to Apolipoproteins E

Share to Cognitive Dysfunction

Share to Genotype

Source

Open in PubMed Open full text

Identifiers

PMID: 36468416
DOI: 10.1111/cns.14038
PMCID: PMC9873529

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of APOE ε2 allele on basal forebrain functional connectivity in mild cognitive impairment.PMID 36468416Read ↗

Basal forebrain volume is associated with cortical amyloid burden in cognitively unimpaired older adults at varying genetic risk for Alzheimer’s diseaseSemantic proximity Read ↗

Brain Homotopic Connectivity in Mild Cognitive Impairment APOE-ε4 Carriers.Semantic proximity Read ↗

The effects of APOE on the functional architecture of the resting brain.Semantic proximity Read ↗

Influence of the APOE ε4 allele and mild cognitive impairment diagnosis in the disruption of the MEG resting state functional connectivity in sources space.Semantic proximity Read ↗

Genotypic effects of APOE-ε4 on resting-state connectivity in cognitively intact individuals support functional brain compensation.Semantic proximity Read ↗

Protective effect of APOE epsilon 2 on intrinsic functional connectivity of the entorhinal cortex is associated with better episodic memory in elderly individuals with risk factors for Alzheimer's disease.Semantic proximity Read ↗

Distinct neural correlates of episodic memory among apolipoprotein E alleles in cognitively normal elderly.Semantic proximity Read ↗

APOE-ε4 Shapes the Cerebral Organization in Cognitively Intact Individuals as Reflected by Structural Gray Matter Networks.Semantic proximity Read ↗

APOE ε2 allele is associated with larger regional cortical thicknesses and volumes.Semantic proximity Read ↗

Genetic association of apolipoprotein E genotype with EEG alpha rhythm slowing and functional brain network alterations during normal agingSemantic proximity Read ↗

APOE ε4-related structural vulnerability in mild cognitive impairment: a subsystem-based analysis of the default mode networkSemantic proximity Read ↗

Modulation on brain gray matter activity and white matter integrity by APOE ε4 risk gene in cognitively intact elderly: A multimodal neuroimaging study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.