Article
Grey matter atrophy of basal forebrain and hippocampus in mild cognitive impairment.
Journal of neurology, neurosurgery, and psychiatry - 1 May 2011
Zhang Haobo, Trollor Julian N, Wen Wei, Zhu Wanlin, Crawford John D, Kochan Nicole A, Slavin Melissa J, Brodaty Henry, Reppermund Simone, Kang Kristan, Mather Karen A, Sachdev Perminder S
Abstract excerpt
The basal forebrain area (BFA) is closely connected to the hippocampus by virtue of cholinergic neuronal projections. Structural neuroimaging studies have shown reduced volumes of both structures in Alzheimer's disease and its prodromal stage mild cognitive impairment (MCI), but generally not in the same investigation. By combining voxel based morphometry and region of interest methods, we measured the grey...
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