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Article

Decomposing heritability and genetic covariance by direct and indirect effect paths.

PLoS genetics - 1 Jan 2023

Song Jie, Zou Yiqing, Wu Yuchang, Miao Jiacheng, Yu Ze, Fletcher Jason M, Lu Qiongshi

Abstract excerpt

Estimation of heritability and genetic covariance is crucial for quantifying and understanding complex trait genetic architecture and is employed in almost all recent genome-wide association studies (GWAS). However, many existing approaches for heritability estimation and almost all methods for estimating genetic correlation ignore the presence of indirect genetic effects, i.e., genotype-phenotype associations...

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Identifiers

PMID: 36689559
DOI: 10.1371/journal.pgen.1010620
PMCID: PMC9894552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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