Article

KLF4 promotes a KRT13+ hillock-like state in lung squamous cell carcinoma

2025-03-13

Abstract excerpt

Lung squamous cell carcinoma (LUSC) is a basal-like subtype of lung cancer with limited treatment options. While prior studies have identified tumour-propagating cell states in squamous tumours, the broader landscape of intra-tumoural heterogeneity within LUSC remains poorly understood. Here, we employ Sox2-driven mouse models, organoid cultures, and single-cell transcriptomic analyses to uncover previously unreco...

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Literature Corpus work: 92566aa1-0466-5692-8968-ed5083e6b539
DOI: 10.1101/2025.03.10.641898

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