Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell Carcinoma from Different Cells of Origin

1 Oct 2016

Abstract excerpt

Lung squamous cell carcinoma (LSCC) is a devastating malignancy with no effective treatments, due to its complex genomic profile. Therefore, preclinical models mimicking its salient features are urgently needed. Here we describe mouse models bearing various combinations of genetic lesions predominantly found in human LSCC. We show that SOX2 but not FGFR1 overexpression in tracheobronchial basal cells combined...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Fibroblast Growth Factor Research
Share to Neonatal Respiratory Health Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27728803
DOI: 10.1016/j.ccell.2016.09.001

Provenance

PubMed metadata and Literature Corpus relationships.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SOX2 Is the Determining Oncogenic Switch in Promoting Lung Squamous Cell Carcinoma from Different Cells of OriginPMID 27728803Read ↗

Evidence That SOX2 Overexpression Is Oncogenic in the LungSemantic proximity Read ↗

Sox2 Cooperates with Lkb1 Loss in a Mouse Model of Squamous Cell Lung CancerSemantic proximity Read ↗

Mapping lung squamous cell carcinoma pathogenesis through in vitro and in vivo modelsSemantic proximity Read ↗

A human model to deconvolve genotype-phenotype causations in lung squamous cell carcinomaSemantic proximity Read ↗

A novel human model to deconvolve cell-intrinsic phenotypes of genetically dysregulated pathways in lung squamous cell carcinomaSemantic proximity Read ↗

The role of SOX2 in small cell lung cancer, lung adenocarcinoma and squamous cell carcinoma of the lung.Semantic proximity Read ↗

Cancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer cocultureSemantic proximity Read ↗

Exploiting a novel organotypic model of SOX2-driven early squamous lung cancer to identify potential routes to chemopreventionSemantic proximity Read ↗

Sox2 Is an Oncogenic Driver of Small-Cell Lung Cancer and Promotes the Classic Neuroendocrine SubtypeSemantic proximity Read ↗

Polyclonal-Monoclonal Transition in Lung Squamous Cell Carcinoma EvolutionSemantic proximity Read ↗

KLF4 promotes a KRT13+ hillock-like state in lung squamous cell carcinomaSemantic proximity Read ↗

BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous cell carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.