Article

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

2024-12-06

Abstract excerpt

<h4>Background</h4> Cellular plasticity, involving loss of lineage determination and emergence of hybrid cell states, plays a pivotal role in non-small cell lung cancer (NSCLC) disease progression and therapy resistance. However, the full spectrum of atypical states generated in human NSCLC and the pathways that regulate them are yet to be fully elucidated. Here we examine the role of developmental programmes, al...

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Literature Corpus work: 82226df3-4222-564f-92ca-4c53ff4e04a5
DOI: 10.1101/2024.12.03.626626

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