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Mapping lung squamous cell carcinoma pathogenesis through in vitro and in vivo models

5 Aug 2021

Abstract excerpt

Lung cancer is the main cause of cancer death worldwide, with lung squamous cell carcinoma (LUSC) being the second most frequent subtype. Preclinical LUSC models recapitulating human disease pathogenesis are key for the development of early intervention approaches and improved therapies. Here, we review advances and challenges in the generation of LUSC models, from 2D and 3D cultures, to murine models. We discuss...

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PMID: 34354223
DOI: 10.1038/s42003-021-02470-x

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