Article

Basal cell of origin resolves neuroendocrine–tuft lineage plasticity in cancer

2024-11-15

Abstract excerpt

<h4>Summary paragraph</h4> Neuroendocrine and tuft cells are rare, chemosensory epithelial lineages defined by expression of ASCL1 and POU2F3 transcription factors, respectively 1,2 . Neuroendocrine cancers, including small cell lung cancer (SCLC), frequently display tuft-like subsets, a feature linked to poor patient outcomes 3–13 . The mechanisms driving neuroendocrine–tuft tumour heterogeneity, and the origi...

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Literature Corpus work: 74e966a0-6c16-512d-ba59-4cc5fec7d26c
DOI: 10.1101/2024.11.13.623500

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