Article

Mutation divergence over space in tumour expansion

2022-12-22

Abstract excerpt

<h4>ABSTRACT</h4> Mutation accumulation in tumour evolution is one major cause of intra-tumour heterogeneity (ITH), which often leads to drug resistance during treatment. Previous studies with multi-region sequencing have shown that mutation divergence among samples within the patient is common, and the importance of spatial sampling to obtain a complete picture in tumour measurements. However, quantitative compa...

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Literature Corpus work: 92426952-9ce5-5a58-aaa9-0f5e28796911
DOI: 10.1101/2022.12.21.521509

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