Article

Quantification of subclonal selection in cancer from bulk sequencing data

2016-12-22

Abstract excerpt

Recent studies have identified prevalent subclonal architectures within many cancer types. However, the temporal evolutionary dynamics that produce these subclonal architectures remain unknown. Here we measure evolutionary dynamics in primary human cancers using computational modelling of clonal selection applied to high throughput sequencing data. Our approach simultaneously determines the subclonal architecture...

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Literature Corpus work: b6dcd323-d587-5188-b2d5-c350533a994e
DOI: 10.1101/096305

Open publication

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