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Article

Mutation divergence over space in tumour expansion.

Journal of the Royal Society, Interface - 1 Nov 2023

Li Haiyang, Yang Zixuan, Tu Fengyu, Deng Lijuan, Han Yuqing, Fu Xing, Wang Long, Gu Di, Werner Benjamin, Huang Weini

Abstract excerpt

Mutation accumulation in tumour evolution is one major cause of intra-tumour heterogeneity (ITH), which often leads to drug resistance during treatment. Previous studies with multi-region sequencing have shown that mutation divergence among samples within the patient is common, and the importance of spatial sampling to obtain a complete picture in tumour measurements. However, quantitative comparisons of the...

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Identifiers

PMID: 37989227
DOI: 10.1098/rsif.2023.0542
PMCID: PMC10681009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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