Article

Estimating the effect size of a hidden causal factor between SNPs and a continuous trait: a mediation model approach

2022-06-29

Abstract excerpt

<h4>Background</h4> Observational studies and Mendelian randomization experiments have been used to identify many causal factors for complex traits in humans. Given a set of causal factors, it is important to understand the extent to which these causal factors explain some, all, or none of the genetic heritability, as measured by single-nucleotide polymorphisms (SNPs) that are associated with the trait. Using the...

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Literature Corpus work: 922c4caf-5aaa-5652-8c5e-07a3e0a2491f
DOI: 10.1101/2022.06.28.497617

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