Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A mediation analysis framework based on variance component to remove genetic confounding effect.

Journal of human genetics - 1 Jul 2024

Dong Zihan, Zhao Hongyu, DeWan Andrew T

Abstract excerpt

Identification of pleiotropy at the single nucleotide polymorphism (SNP) level provides valuable insights into shared genetic signals among phenotypes. One approach to study these signals is through mediation analysis, which dissects the total effect of a SNP on the outcome into a direct effect and an indirect effect through a mediator. However, estimated effects from mediation analysis can be confounded by the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computer Simulation
Share to Genetic Pleiotropy
Share to Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Likelihood Functions

Share to Mediation Analysis

Share to Models, Genetic

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 38528049
DOI: 10.1038/s10038-024-01232-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A mediation analysis framework based on variance component to remove genetic confounding effect.PMID 38528049Read ↗

The identification of mediating effects using genome-based restricted maximum likelihood estimation.Semantic proximity Read ↗

A novel statistical framework for meta-analysis of total mediation effect with high dimensional omics mediators in large-scale genomic consortiaSemantic proximity Read ↗

Generalized multi-SNP mediation intersection-union test.Semantic proximity Read ↗

MELODY: Mediation Analysis in Logistic Regression for High-Dimensional Mediators and a Binary OutcomeSemantic proximity Read ↗

Estimating the effect size of a hidden causal factor between SNPs and a continuous trait: a mediation model approach.Semantic proximity Read ↗

Integrative modeling of multi-platform genomic data under the framework of mediation analysis.Semantic proximity Read ↗

Penalized mediation models for multivariate data.Semantic proximity Read ↗

Multivariable Mendelian Randomization and Mediation.Semantic proximity Read ↗

Estimating the effect size of a hidden causal factor between SNPs and a continuous trait: a mediation model approachSemantic proximity Read ↗

Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysis.Semantic proximity Read ↗

Mendelian randomisation for mediation analysis: current methods and challenges for implementation.Semantic proximity Read ↗

Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.